中文摘要：

Kashin BeckDisease(KBD)isachronic,en demicosteoarthritisaffectingover0.81millionspa tientsand101millionsofpeopleatriskinChina[1]. Thebasicpathologicalfeaturesofthediseaseis chondrocytesdegenerationandnecrosisinthedeep zoneofarticularcartilageandgrowthplatecarti lage,whichcanresultinsecondaryosteoarthritis. Theultrastructuralchangesshowedcondensationand vacuolizationofcytoplasm,andcalciumgranules werefoundtobedepositedoncellplasmamem brane.Clinically,thediseasemanifeststheenlarged inter phalangealjoints,...