中文摘要：

目的 探讨7TMR辅助猴脑内丘脑定位注射的价值。方法对20只猴子的双侧丘脑均进行定位穿刺，8只猴子根据恒河猴脑部定位图谱将穿刺针插到预定为丘脑的位置，术后2d行MR扫描验证穿刺的位置并做病理检查证实。通过穿刺针的位置对定位方法进行改进后，剩余12只猴子按改进的定位方法进行穿刺，术后2d做MR扫描验证穿刺的结果并对其进行病理证实。结果改进定位方法前后各有1只猴子因为麻醉状态不稳定而缺失MR扫描结果，改进定位方法前11次准确定位于丘脑（78．6％），改进定位方法后21次准确定位于丘脑（95．5％）。MR所得结果与病理证实结果一致（88．9％）。结论高分辨能力的7TMR可以改进猴脑内精细解剖和功能结构定位的方法。

英文摘要：

Objective To study the value of the targeted positioning puncture rhesus thalamus under 7T MR guidance. Methods Twenty monkeys underwent bilateral thalamus puncture. Eight monkeys underwent atlas-guided puncture surgery. Two days later, high-resolution MR images at 7T MR of the brain were acquired to conform whether the position of puncture was righ and histological examination was made to evaluate the results of MRI. The method of puncture was improved according to the analysis of the results before, the other twelve monkeys underwent puncture surgery followed the improved method. MRI and histological examination were acquired also after the surgery. Results One monkey before and after improved method lost the chance of MR scan for unstable anesthetized condition. The accurate rates of puncture were in 95.5%and 78.6 % after and before improved method, respectively. The results of MRI were in accordance with the histological results（88.9%）. Conclusion High-resolution 7T MR imaging can directly define the microstructure of the monkey. The method of puncture bilateral cranial targeting into the thalamus in monkeys can be improved with high-resolution 7T MR imaging.