中文摘要：

背景：近年来，中药麻黄用于肥胖症的治疗并有一定的效果，但麻黄对围绝经期妇女的肥胖是否有效有待研究。目的：观察口服麻黄水煎剂对去卵巢肥胖大鼠体质量、血脂、血糖及激素水平的影响。设计：完全随机分组设计，对照实验。单位：兰州大学基础医学院生理学和心理学研究所。材料：实验于2006-02／06在甘肃省新药临床前研究重点实验室和兰州大学基础医学院生理学和心理学研究所实验室完成。选用健康雌性SD大鼠44只，随机分为4组，每组11只，分别为假手术组，去卵巢组，雌激素替代治疗组和麻黄组。方法：①大鼠用氯胺酮（110m异／kg）麻醉，除假手术组外全部行双侧去卵巢术。假手术组进行同样的手术过程，但不切除卵巢。②假手术组和去卵巢组大鼠术后每天皮下注射芝麻油（0．2mL／只），持续到实验结束。③雌激素替代治疗组大鼠术后每天皮下注射雌激素（1mg／kg），持续到实验结束。④麻黄组大鼠术后自然口服1％浓度的麻黄水煎剂，到第6天浓度逐渐增至8％，持续到实验结束。⑤每天测定大鼠的摄食量，每隔10天测定大鼠的体质量。⑥实验结束时，所有实验动物禁食12h后，颈动脉取血测定血清指标。同时测定体质量和体长计算李氏指数[（g）×10^3体长（cm）]。主要观察指标：①不同时间点各组大鼠体质量及李氏指数。②不同时间点各组大鼠摄食量结果。③大鼠血脂和血糖水平。④不同组别大鼠血清雌激素、孕激素和胰岛素水平。结果：大鼠44只全部进入结果分析。①不同时间点各组大鼠体质量及李氏指数结果：去卵巢组大鼠实验开始第20，30，40，50天体质量分别为（256．4±1413），（27.13±16．1），（276．4±12．7），（285．7±24．2）g，均大于假手术组大鼠相应时间点[（226．5±11．5），（241．8±12．6），（243．1±1

英文摘要：

BACKGROUND： Ephedra, a Chinese medicine, is often used to treat obesity with relatively satisfying results recently. However, the effects of Ephedra on the perimenopausal and postmenopausal obese women remain unclear. OBJECTIVE： To observe the effects of oral Ephedra decoction on body mass and the levels of blood lipids, blood glucose and hormone in ovarietomized obese rats. DESIGN： A completely randomized and controlled experiment. SETTING： Institute of Physiology and Psychology, School of Basic Medical Sciences, Lanzhou University. MATERIALS： The experiment was performed in the Key Laboratory of Pre-clinical Study for New Drugs of Gansu Province and the Laboratory of Institute of Physiology and Psychology, School of Basic Medical Sciences, Lanzhou University from February 2006 to June 2006. Forty-four healthy female SD rats were randomly divided into four groups with 11 rats in each group, namely sham-operated group, ovariectomized group, estrogen replacement therapy group and Ephedra group. METHODS：① After having been narcotized by cloraminone （110 mg/kg）, rats were underwent a bilateral ovariectomy except those in the sham-operated group, which were also operated, but their ovaries were not cut off.②Rats in the sham-operated group and ovariectomized group were subcutaneously injected with sesame oil （0.2 mL/each rat） every day postoperatively till the end of the experiment.③The rats in the estrogen replacement therapy group were given estradiol （1 mg/kg） by subcutaneous injection every day postoperatively till the end of the experiment. ④The rats in the Ephedra group freely drank 1% water extracts from Ephedra postoperatively, later the concentration of Ephedra gradually increased to 8% on the sixth day, which lasted until the end of the experiment. ⑤The food intake was monitored daily, and body mass was measured every ten days.⑥ At the end of the experiment, all the rats were fasted for 12 hours and collected blood samples for the measurement of serum indexes. The body mas