目的:经微创手术制备膝关节软骨缺损动物模型,减少因手术创伤造成对实验结果的影响。方法:关节镜下对9只山羊(9膝)进行关节面钻孔术,造成软骨缺损模型,对其缺损位置进行准确定位。结果:9只山羊(9膝)均在关节镜下顺利进行了关节软骨缺损模型的建立,并进行了缺损部位的定位。结论:对比开放性手术,经关节镜制备关节缺损模型是一种对实验干预最少的微创方法,有助于减少手术本身造成的实验误差。
Objective: To construct animal models of articular cartilage lesions in the knee of goats by arthroscopy to minimize the surgical injury. Methods: Subchondral drilling to create the chondral defect on articular cartilage were performed on 9 goats (9 joints) by arthroscope. Results: The chondral defect models were successefully constructed on 9 goats (9 joints) and accurately located by arthroscopy. Conclusion: Preparing animal models of chondral defects by arthroscopy result in fewer injuries and experimental errors as compared with open surgery.