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中文摘要：
目的：观察正常大鼠触液核内BKca-α分布及其在神经病理性疼痛过程中的表达变化,探讨触液核在神经病理性疼痛中的作用。方法：采用霍乱毒素B结合辣根过氧化酶（CB-HRP）和BKca-α免疫荧光双重标记技术,观测大鼠触液核中BKca-α在正常及慢性坐骨神经压迫损伤（chronic constriction injury,CCI）大鼠的表达变化。结果：正常和CCI大鼠触液核内存在BKca-α;在CCI大鼠,大鼠热痛觉及机械痛觉阈值下降,且触液核内BKca-α表达的数目也相应减少,和对照组比较有显著差异。结论：触液核BKca-α的降低可能参与神经病理性疼痛。
英文摘要：
Objective ： To observe the expression of BKca-α in CSF-contacting nucleus（CSF-CN） of normal rats and changes in it＇s expression during the process of neuropathic pain,and to discuss the role of BKca-αin CSF-CN in neuropathic pain.Methods： The CB-HRP/BKca-α immunofluorescence double-labeling method was used to observe the expression of BKca-α in CSF-CN in normal and chronic constriction injury（CCI） rats.Results： BKca-α was found in CSF-CN in normal and CCI rats.The thresholds of thermal and mechanical pain were remarkably decreased in CCI rats.Compared with sham rats,the expression of BKca-α in CSF-CN was decreased in CCI rats.Conclusion： The decrease of BKca-α in CSF-CN may play an important role in neuropathic pain.
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