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中文摘要：
目的：探讨甘遂半夏汤中甘遂不同入药方式对癌性腹水模型大鼠醛固酮及肾功能的影响。方法：Wistar大鼠80只，随机分为4组：空白组、模型组、甘遂半夏汤（甘遂入汤剂）组、甘遂半夏汤（甘遂研末）组，除空白组外均腹腔注射Walker-256癌细胞造模。灌胃10d后，取材并检测血浆醛固酮含量及肾功能相关指标，观察大鼠肾组织切片。结果：甘遂半夏汤中甘遂不论人汤剂煎煮还是研末服用都能显著降低癌性腹水大鼠醛固酮含量，而甘遂入汤剂煎煮对大鼠肾毒性较小。结论：甘遂半夏汤中甘遂入汤剂煎煮的方法肾毒性小，且具有良好的降低醛固酮含量的效果，本研究为临床用药提供了参考和依据。
英文摘要：
Objective： To study on the influence of gansui with different extracting manners in Gansui Banxia decoction on aldosterone and functions of kidneys on rat models of malignant ascites. Methods： 80 Wistar rats were divided into four groups： blank group, model group, Gansui Banxia Decoction （gansni decocted together with other herb）, Gansui Banxia Decoction （gansui powder into the ready decoction）. The walker-256 carcinosarcoma cells were injected intraperitoneally into the rats except blank group. Examine changes of aldosterone, renal function and morphology of rats. Results： The levels of ALD in each medication groups were significantly lower than in model group. Gansui Banxia decoction （gansni decocted together with other herbs） was with less nephrotoxicity. Conclusion： Gansui Banxia Decoction （gansui decocted together with other herbs） with less nephrotoxicity at the same time reduces the level of ALD significantly. The experiment also proves the theoretical basis for clinic.
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