中文摘要：

客观: 选择 carcinoembryonic 抗原(CEA ) 的特定的恰当的 amer，为癌症的最吸引人的分子之一指向治疗和成像。方法：在 vitro 选择的七个回合对净化的 CEA 蛋白质被执行。调停 Ligand 的目标纯化和 Co-immunoprecipitation 被采用验证恰当的 amer 的特定的绑定到净化并且本国的蛋白质独立。能绑两个的 ResultsrThe CEA 特定的恰当的 amer 净化，有高特性的本国的蛋白质被获得。结论: 这是 CEA 特定的 apatmer 被生产的第一次。在这的结果学习以后为 CEA-aptamer 的进一步的调查和申请提供初步的证据。

英文摘要：

Objective：To select the specific aptamer of carcinoembryonic antigen （CEA）, one of the most attractive molecule for cancer target therapy and imaging. Methods： Seven rounds in vitro selection were performed against the purified CEA protein. Ligand-mediated target purification and Co-immunoprecipitation were adopted to verify the specific binding of the aptamer to the purified and native protein separately. Results：The CEA-specific aptamer which can bind both the purified and native protein with the high specificity was obtained. Conclusion：This is the first time the CEA specific apatmer was produced. The results in this study provides the preliminary evidence for further investigation and application of CEA-aptamer in the future.