中文摘要：

目的：从化学角度探查黄芪对广、粉防己的影响机制。方法：采用HPLC法测定广防己及其配伍黄芪水提物中马兜铃酸含量;粉防己及其配伍黄芪水提物中粉防己碱的含量。结果：广防己和广防己配伍黄芪水提物中马兜铃酸转移率分别为86.21%,51.86%;粉防己和粉防己配伍黄芪水提物中粉防己碱转移率分别为56.45%,63.03%。结论：广防己中的马兜铃酸和粉防己中的粉防己碱在水提过程中均有损耗,其配伍黄芪则分别增加和减少马兜铃酸和粉防己碱的溶出率。该结果为黄芪与广、粉防己配伍的减毒、增效作用提供了一定的理解,提示复方汤药制备对药物不同成分溶出的影响是中药配伍机制的重要环节之一。

英文摘要：

Objective：To study the chemical mechanism of Astragali Radix influence on Aristolochiae Fangchi and Stephania Tetrandra.Method： Aristolochic acid（AA） in aqueous extract of Aristolochiae Fangchi combined with Astragali radix and Tet in the aqueous extract of Stephania Tetrandra combined with Astragali Radix were determined by the method of HPLC.Result： The transfer rate of AA was 86.21% and 51.86% separately in aqueous extract of Aristolochiae fangchi and combined with Astragali Radix.The transfer rate of Tet was 56.45% and 63.03% separately in aqueous extract of Stephania Tetrandra and combined with Astragali Radix.Conclusion： The AA and Tet were all lose in the process of water extract.Matching that Astragali radix could decrease the dissolution rate of AA and increase the dissolution rat of Tet.