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中文摘要：
Ca^2＋释放激活Ca^2＋（CRAC）通道是位于非兴奋性细胞质膜上的慢Ca^2＋通道,是非兴奋性细胞（尤其T淋巴细胞和HEK 293细胞）中胞外Ca^2＋进入细胞内的主要途径.Ca^2＋内流是T淋巴细胞激活的最重要的生理生化特征之一.Orai1蛋白单体是组成CRAC通道的亚基,4个Orai1蛋白亚基构成一个四聚体CRAC通道.内质网Ca^2＋浓度的降低使得STIM1发生定向运动并产生聚集,从而激活了CRAC通道.STIM1蛋白把内质网Ca^2＋的损耗与CRAC通道上的Ca^2＋内流联系起来,行使了Ca^2＋浓度感受器的功能.
英文摘要：
Calcium-release-activated calcium （CRAC） channel is a slow Ca^2＋ channel, which locates in the plasma membrane in non-excitable cells. CRAC channel is the major Ca^2＋ entry pathway in non-excitable cells, especially in T lymphocytes and HEK 293 ceils. Ca^2＋ influx is one of the most important physiological-biochemical characteristics of T lymphocytes cell. Orail is the subunit of CRAC channel, and four Orail monomers constitute one tetrameric CRAC channel. STIM1 functions as the missing link hetween endoplasmic reticulum Ca^2＋ depletion and CRAC influx. At present, STIM1 has been widely accepted as a Ca^2＋ sensor that relays the store depletion information to plasma membrane and thus to activate CRAC channel.
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