中文摘要：

目的：比较双、单相抑郁患者前扣带回部位大脑代谢物水平。方法：用氢质子磁共振频谱技术检测双、单相抑郁和正常对照组（各组11例）大脑前扣带回部位代谢物水平。联合运用LCModel和SAGE软件对前扣带回部位的代谢物进行定量。结果：双相抑郁组在前扣带回部位谷氨酸＋谷氨酰胺水平较正常对照和单相抑郁组均升高。前扣带回部位N-乙酰基天门冬氨酸、肌酸、胆碱、肌醇在三组被试间均无统计学意义。结论：双相抑郁在前扣带回部位存在谷氨酸系统失衡,而单相抑郁则否。这可能是两种疾病不同病理生理学机制。

英文摘要：

Objective：To compare the metabolite levels in anterior cingulate cortex of bipolar and unipolar depression patients.Methods：The bipolar and unipolardepression patients and healthy controls（11 cases in each group）underwent routine MRI scan and protonmagnetic resonance spectrosco-py.The absolute metabolite concentrations in anterior cingulat ecortex（ACC） were measured using LCModel and SAGE software.Results：The bipolar depression group showed significantly higher levels of Glx in their ACC compared with uinpolar depression and control groups.No difference in other brain metabolites among groups.Conclusion：There is glutamate system imbalance in ACC of bipolar depression,while not in unipolar depression.This indicates there may be different pathophysiology between two diseases.