以间苯三酚和3,3-二甲基烯丙酸为起始原料,通过苄基保护、甲基化、脱保护基、Clemmenson还原、乙酰化、Fries重排、Baker-Venkataraman重排和成环等10步反应,以18.2%的总收率合成了1个新型异戊烯并环黄酮化合物BE-1C,其结构经1H NMR,13C NMR和HR-MS(ESI-TOF)表征。
One novel isopentenyl six-membered fused flavonoid(BE-1C) was synthesized with 18.2% total yield via benzyl protection, methylation, Clemmenson reduction, acylation, Fries rearrangement, Baker-Venkataraman rearrangement and cyclization reaction etc. using m-trihydroxybenzene and 3,3- propionie acid as the starting materials. The structure was characterized by 1H NMR, 13C NMR and HR-MS (ESI-TOF).