中文摘要：

病理性瘢痕主要包括增生性瘢痕和瘢痕疙瘩,成纤维细胞是其发生、发展的主体细胞。正常皮肤、增生性瘢痕真皮浅层和真皮深层的成纤维细胞以及瘢痕疙瘩组织中不同层次、不同部位的成纤维细胞在细胞形态、功能、分子表型等方面均具有异质性。真皮深层的成纤维细胞可能是形成增生性瘢痕的主要细胞来源;而瘢痕疙瘩的形成则包含了真皮浅层和深层成纤维细胞的共同作用,并与其组织内不同部位成纤维细胞的异质性有关。

英文摘要：

Pathological scars include hypertrophic scar and keloid, and fibroblasts are the major constituents of the genesis and development. The fibroblasts from different sources （ such as normal skin, superficial dermis and deep dermis of hypertrophic scar） are different in morphology,function and molecular phenotype. Deep dermal fibroblasts may be a major source of ceils contributed to hypertrophic scar formation, while keloid formation is the result of actions of fibroblasts from both superficial and deep dermis and is affected by fibroblastic heterogeneity at different parts of internal keloid tissues and different anatomical sites, which may attribute to interactions of fibroblasts with their niche.