中文摘要：

目的探讨MR扩散张量成像（DTI）观察豆状核年龄相关性变化的价值与意义。方法69名健康志愿者纳入本研究。入组对象按年龄分为3组：≤30岁（I）组，22例；31～50岁（Ⅱ）组，24例；〉50岁（Ⅲ）组，23例。利用DTI分别测量受试者大脑左右两侧壳核、苍白球的表观扩散系数（ADC）值、部分各向异性（FA）值及扩散张量特征值λ1、λ2、λ3。分析不同年龄组间ADC、FA、λ1、λ2、λ3值的差异及与年龄的相关性。结果I、Ⅱ、Ⅲ组的壳核ADC值分别为：（6．68±0．40）×10^-4、（6．47±0．36）×10^-4、（6．44±0．34）×10^-4mm^2／s，苍白球ADC值分别为：（6．13±0．50）×10^-4、（6．05±0．33）×10^-4、（6．05±0．52）×10$-4mm^2／s。I、Ⅱ、Ⅲ组的壳核FA值分别为：0．20±0．03、0．23±0．03、0．25±0．03，苍白球FA值分别为：0.35±0．03、0．36±0．03、0．37±0．04。各年龄组内壳核ADC值大于苍白球，而FA值小于苍白球。壳核FA值的组问差异有统计学意义（F=10．082，P=0.000），壳核I、Ⅱ、Ⅲ组入，值分别为（5．35±0．45）×10^-4、（5．04±0．46）×10^-4、（4．90±0．44）×10^-4mm^2／s，差异亦有统计学意义（F=5．675，P=0．005）；壳核FA值与年龄呈正相关（r=0．555，P〈0．01），λ3值与年龄呈负相关（r=-0.440，P〈0．01）。结论壳核FA值随年龄的增长而上升，λ3值随年龄的增长而下降。

英文摘要：

Objective To quantify the values of fractional anisotropy （FA） and eigenvalues （h） using diffusion tensor imaging in the putamen and globus pallidus respectively, and to investigate their relationship with aging. Methods Sixty nine normal volunteers （38 men and 31 women; age range, 20-80 years; mean age, 42 years） were studied. All the participants were divided into three groups （ group I ：≤30 years, group Ⅱ： 31-50 years, group Ⅲ： 〉50 years）. The values of ADC, FA, λ1, λ2 and λ3 in putamen and globus pallidus were calculated after diffusion tensor scanning, and then analyzed the differences between the two tissues. The differences of ADC, FA, λ1 , λ2 and λ3 values among age groups were analyzed by using analysis of variance （ANOVA）, and their relationship with age were accessed by using Pearson correlation. Results Between the correspondent age groups, the ADC value was higher in the putamen [ （6. 68±0. 40） ×10^-4, （6. 47±0. 36）×10^-4, （6.44±0. 34）×10^-4 mm^2/s] than that in the golbus pallidus [ （6. 13±0. 50）×10^-4, （ 6. 05±0. 33 ）×10^-4, （6.05×0. 52）×10^-4 mm^2/s ], and the value of FA in the putamen （0. 20±0. 03, 0. 23±0. 03, 0. 25±0. 03 ） was lower than that in the globus pallidus （0. 35±0. 03, 0. 36±0. 03, 0. 37±0. 04 ）. ANOVA analysis of the FA value among age groups revealed there were significant differences in the putamen （F = 10.082,P =0.000） , and the same analysis of eigenvalue λ3 in the putamen also showed significant differences （F =5.675 ,P =0. 005 ）. The FA value in the putamen was significantly elevated with aging （ r = 0. 555, P 〈 0. 01 ） , and eigenvalue λ3 in the putamen showed age-related decline （r = -0. 440, P 〈0.01 ）. ANOVA and Pearson correlation analysis of all parameters in the globus pallidus showed no significant differences. Condusion The phenomenon of age-related elevation of the FA value lied in the putamen, not in the whole lenticular nclei, and λ3 in the putamen showe