中文摘要：

实体瘤的发生发展常伴随着细胞外基质的异常沉积、交联和基质刚度增加．基质刚度增加和肿瘤细胞软化引起肿瘤微环境的力学异质性．基质力学通过影响肿瘤细胞的增殖、迁移、转移、上皮间质转换、肿瘤干细胞特性和耐药性等调控肿瘤的发生、恶性转变和转移．研究基质力学对肿瘤发生发展的影响不仅可深化对肿瘤发展的认识，也可为研究新的诊治方法 提供理论基础．本文论述了细胞外基质力学特性对肿瘤发生发展及肿瘤细胞生物学行为影响的研究进展，并展望了其发展前景．

英文摘要：

The development of solid tumor is often accompanied by extracellular matrix abnormal deposition, cross-linking and stiffening. Extracellular matrix stiffening and tumor cell softening contribute to the mechanical heterogeneity of tumor microenvironment. Matrix mechanics regulates tumorigenesis, malignancy, metastasis of tumor by affecting tumor cells proliferation, migration, epithelial-mesenchymal transition, properties of cancer stem cells and drug resistance. To study the effect of matrix mechanics on cancer development can not only deepen the understanding of cancer development, but also provide theoretical basis for developing new treatment strategy. In this paper, the research advances in the effect of extracellular matrix mechanical characteristics on tumor development and tumor cell biological behavior was summarized and its development prospect was also discussed.