中文摘要：

目的比较度洛西汀与氟西汀对首发抑郁症患者疗效及认知功能的影响。方法首发抑郁症患者74例随机分为度洛西汀组与氟西汀组，对两组在治疗前、治疗12周后进行P300及汉密尔顿抑郁量表的评定。与研究组性别、年龄匹配的正常人作对照，比较P300的变化。结果与对照组相比．度洛西汀组与氟西汀组p300的P2、N2、P3潜伏期及反应时间明显延长，而P300的P2、N2、P3波幅降低，具有统计学差异：治疗后，度洛西汀组与氟西汀组P300的P2、N2、P3潜伏期及反应时间较治疗前减少且波幅升高，具有统计学差异；度洛西汀组与氟西汀组，P300指标的组间比较，无统计学差异。12周末，疗效比较无差异。治疗前后的P300潜伏期、波幅及反应时间均与其治疗前后HAMD评分无显著性相关性。结论度洛西汀与氟西汀均能有效治疗首发抑郁患者．且具有改善其认知功能作用。

英文摘要：

Objective To compare the effect and the influence between duloxetine and fluoxetine on the cognitive function of patients with first episode depression. Methods 74 patients with first episode depression were randomly divided into duloxetine group and fluoxetine group. P300 and Hamilton depression scale （HAMD） were used to evaluate the therapeutic efficacy before and 12 weeks after the treatment. Compared with 30 normal persons with age and sex matched （control group）, the change of P300 was observed. Results Compared with the control group, the P2, N2 and P3 latency and reactive time of P300 in duloxetine group and fluoxetine group were significantly prolonged, while the amplitude decreased, and the differences were statistically significant. After treatment, the P2, N2 and P3 latency and reactive time of P300 in duloxetine group and fluoxetine group significantly reduced and volatility increased with significant difference compared with the condition before treatment. The differences of P300 indices between duloxetine group and fluoxetine group were not statistically significant; 12 weeks after the treatment, the efficacy between two groups had no significant difference. No significant correlation was found between HAMD scores before and after treatment, P300 latency, amplitude and reaction time before and after treatment. Conclusions Duloxetine and fluoxetine are effective in the treatment of patients with first episode depression, which play the role in improving patients＇ cognitive function.