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中文摘要：
以5-甲酰基嘧啶核苷为原料,经与（取代）苯乙酮缩合,得到了一系列含有嘧啶核苷和查尔酮两种优势结构单元的杂化体.生物活性研究结果表明,其中的一些杂化体具有显著的抗利什曼原虫活性,从而为新药的开发提供了有价值的先导化合物和构效关系信息.
英文摘要：
In this paper, a group of pyrimidine nucleoside-chalcone hybrids were conveniently prepared through condensing 5-formyl pyrimidine nucleosides with（substituted） acetophenones under the promotion of aqueous sodium hydroxide. The hybrid compounds were then evaluated as potential antileishmanial agents and some of them showed promisingly potent activities.
同期刊论文项目
同项目期刊论文
Copper-catalyzed N- and O-arylation of Amides: Alternative Approaches to 3,4-Dihydroquinolin-2-ones,
Selective Access to 3-Cyano-1H-indoles, 9H-Pyrimido[4,5-b]indoles, or 9H-Pyrido[2,3-b]indoles throug
Synthesis of Pyrazolo[5,1？a]isoindoles and Pyrazolo[5,1？a]isoindole-3-carboxamides through One-Pot C
Synthesis of 1,2,3-Trisubstituted Indolizines, Pyrrolo[1,2-a]quinolines, and Pyrrolo[2,1-a]isoquinol
Iodine-Initiated Domino Reaction of Hepta-1,2-dien-6-yn-4-ols and Bronsted Acid Promoted Cyclization
Tandem Reaction of 3-Hydroxyhexa-4,5-allenic Esters: a Novel Access to Diversely Substituted 2H-Pyra
Tunable Synthesis of 3-Acyl-2-naphthols and 3-Substituted Isocoumarins via Jones Reagent Promoted Ca
Synthesis of cyclopentenyl and cyclohexenyl ketones via [3+2] and [4+2] annulations of 1,2-allenic k
Synthesis of Quinazolines and Tetrahydroquinazolines: Copper-Catalyzed Tandem Reactions of 2-Bromobe
One-pot Cascade Reactions of 1-Arylpenta-3,4-dien-2-ones Leading to 2-Arylphenols and Dibenzopyroano
Synthesis of 3-(4-oxo-4H-chromen-3-yl)acrylates through the tandem reaction of 3-(2-buta-2,3-dienoyl
Synthesis of substituted quinoline via copper-catalyzed one-pot cascade reactions of 2-bromobenzalde
One-pot synthesis of 12H-benzo[b]xanthen-12-ones and naphtha[2,3-b]furans from non-naphthalene subst
One-pot Sequential Reactions Featuring a Copper-catalyzed Amination Leading to Pyrido[2,1:2,3]imidaz
Synthesis of Diversely Substituted 2-(Furan-3-yl)acetates from Allenols through Cascade Carbonylatio
Synthesis of 2-Aminoquinoline-3-carboamides and Pyrimido[4,5-b]quinolin-4-ones through Copper-Cataly
Synthesis of Ketones through Microwave Irradiation Promoted Metal-Free Alkylation of Aldehydes by Ac
Synthesis of Naphthalene Amino Esters and Arylnaphthalene Lactone Lignans through Tandem Reactions o
Highly Facile and Regio-selective Synthesis of Pyrazolo[1,5-a]pyrimidines via Reactions of 1,2-Allen
Synthesis of Pyrazolo(1,5-c]quinazoline Derivatives through Copper-Catalyzed Tandem Reaction of 5-(2
Synthesis of Pyrazolo[5,1-a]isoquinolines and 8-Methylenepyrazolo[5,1-a]isoindoles via Regioselectiv
Regioselective Synthesis of Indolo[1,2-c]quinazolines and 11H-Indolo[3,2-c]quinolines via Copper-Cat
Rapid Assembly of Quinazolinone Scaffold via Copper-Catalyzed Tandem Reaction of 2-Bromobenzamides w
Synthesis of Pyrazolo[1,5-c]quinazoline Derivatives through Copper-Catalyzed Tandem Reaction of 5-(2
Zinc-Mediated One-Pot Tandem Reaction of Nitriles with Propargyl Bromides: An Access to 3-Alkynylpyr
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