目的探讨应用单纯多支架重叠技术治疗颅内段椎动脉夹层动脉瘤的临床可行性、安全性及随访结果。方法回顾性分析2008年6月至2014年6月解放军总医院神经内科收治的8例经MRI或数字减影血管造影(DSA)证实为颅内段椎动脉夹层动脉瘤患者的临床资料。男性6例,女性2例,年龄34~62岁,平均46.8岁。8例患者全身麻醉下根据瘤体最大径和迁延长度重叠置入2~3枚不同型号的Solitaire、Neuroform或Wingspan颅内自膨式支架。结果8例患者治疗均获成功,支架定位准确,释放顺利。共置入支架18枚,其中6例置入2枚,2例置入3枚。术前和术后常规采用抗血小板治疗,围手术期无手术相关并发症发生。随访6~48个月,患者无复发症状,生活和工作基本正常。随访期间,8例患者均复查DSA,3例患者动脉瘤完全愈合,4例瘤体缩小,1例瘤体无变化。结论应用单纯多支架重叠技术治疗颅内段椎动脉夹层动脉瘤手术方法简单可行,能促使动脉瘤闭塞或皱缩并降低其破裂出血的风险,提高患者的生存质量。
Objective To evaluate the feasibility, safety, clinical, and angiographic follow-up of only overlapping stents therapy for intracranial vertebral artery dissection aneurysms (VADA). Methods Eight consecutive patients (6 men, 2 women; mean age 46. 8 years ranging from 34 to 62 years) with intracranial VADA admitted to Department of Neurology, Chinese People's Liberation Army General Hospital from June 2008 to June 2014 were retrospectively reviewed. All patients were diagnosed intracranial VADA by MRI or digital subtraction angiography (DSA). All patients were treated by only overlapping stents therapy under general anesthesia. In the endovaseular treatment process 2 to 3 Solitaire, Neuroform or Wingspan self-expandable stents were overlapping implanted in the segment of the aneurysms. All patients received routine antiplatelet therapy before and after endovaseular treatment. Results The operative procedures were succeeded in all patients. Eight patients were implanted 18 stents (2 patients, 3 stents; 6 patients, 2 stents). The stents were located accurately and implanted smoothly, none perioperative complications occurred. All patients lived and worked normally and had no recurrent symptoms on follow-up of 6 to 48 months. All patients performed DSA reexamination on follow-up. The aneurysm blocked in 2 patients, the size lessened in 2 patients, and the size had no change in 3 patients. Conclusions Only overlapping stents therapy for treating intracranial VADA is feasible and has good operation safety. Preliminary follow-up results show that it can reduce the probability of thrombosis or hemorrhage and can improve the patients' life quality.