目的观察早期再进食对轻症急性胰腺炎患者血糖的影响及安全性。方法采用随机对照实验方法,选择157例轻型急性胰腺炎患者,随机分为早期进食组(80例)和正常对照组(77例)。早期进食组以患者腹胀腹痛缓解,有饥饿感为再进食时机。对照组患者以腹胀腹痛消失,腹部柔软,无明显压痛,肠鸣音正常,有饥饿感,并且患者的血淀粉酶、脂肪酶降至参考值上限的2倍以下时为再进食的时机。比较两组患者再进食前后血糖水平的差异及安全性。结果早期进食组和对照组患者再进食时间分别是(4.63±1.59)d和(6.83±2.31)d,差异有统计学意义(P=0.00);两组患者再进食前血糖水平分别是(7.63±3.45)mmol/L和(7.27±3.93)mmol/L,差异无统计学意义(P=0.5424);再进食后出院前两组患者血糖水平分别是(5.94±2.05)mmol/L和(5.56±2.97)mmol/L,差异无统计学意义(P=0.1288)。但早期进食组患者进食后血糖水平显著低于进食前(P=0.0002),而对照组患者再进食前后血糖水平无明显变化(P=0.2060)。结论早期再进食可能有助于轻症急性胰腺炎患者血糖水平的控制。
Objective To explore the influence of early refeeding on blood glucose in patients with mild acute pancreatitis(MAP).Methods Total 157 patients with MAP enrolled the study were divided into early oral refeeding group and control group randomly.When the abdominal distension and abdominal pain were just relieved with hunger sensation,the patients restarted eating for early oral refeeding group.While the abdominal distension and abdominal pain were totally relieved without tenderness,as well as normal bowel sounds,hunger sensation,and the patient's serum amylase and lipase decreased to 2 times of the upper limit of reference value,patients started oral refeeding in control group.The blood glucose levels of the two groups were compared before and after orally refeeding.Results The oral refeeding time were(4.63±1.59) days for early refeeding group and(6.83±2.31) days for control group,which was statistically difference(P=0.00).There was no significant difference in blood glucose levels between early refeeding group and control group before and after oral refeeding(P=0.5424 and P=0.1288,respectively).However,the mean level of blood glucose after oral refeeding in early refeeding group was much lower than that before oral refeedling(P=0.0002),while no difference was found in control group.Conclusion The early oral refeeding seems to be beneficial for the blood glucose control in patients with mild acute pancreatitis.