类风湿关节炎是一种自身免疫性疾病,主要是以血管翳的形成和滑膜炎为病理改变。研究发现血小板活化及其活化产物作为类风湿关节炎一个重要的病理变化和发病因素,贯穿在病程始终,对类风湿关节炎的发生发展极其重要。本文通过对血小板活化机制的分析以及对血小板活化产物与类风湿关节炎之间关系的分析,探讨血小板活化及其活化产物对类风湿关节炎的影响。
Rheumatoid arthritis is a kind of autoimmune disease, whose pathological changes includesynovitis and pannus formation. Previous studies shown that platelet activation and activation products, as animportant rheumatoid arthritis pathological changes and risk factors, are very important for the occurrence anddevelopment of rheumatoid arthritis. This paper focus on the effect of platelet activation and its products onrheumatoid arthritis, and summarize the mechanism of platelet activation and the relationship between the plateletactivation products and rheumatoid arthritis.