邻苯二甲酸酯是一类人工合成的具有广泛用途的化学物质,普遍存在于环境中,其进入人体后分解为次级代谢物,发挥着类雌激素作用,干扰体内激素的调节及内分泌系统的正常功能,导致多种代谢疾病。该文综述了邻苯二甲酸酯暴露与脂肪和糖类代谢及与脂肪细胞分化的关系。
Phthalates are a class of synthetic chemicals with a wide use and easily release to environment. Phthalates enter the body and break down into its secondary metaholites which may play a similar role of estrogen. Phthalates may interfere hormone regulation and the normal function of endocrine system, leading to metabolic diseases. This article focuses on the relationship between phthalates exposure and fat and glucose metabolism and adipoeyte differentiation.