中文摘要：

膜泡运输是真核细胞生命活动的最基本的形式，是大分子物质运输和交流的基础。膜泡运输是起始于运输囊泡在供体膜上的出芽，随后沿细胞骨架定向移动，到达靶位膜的拴留、锚定以及膜融合过程。其中拴留因子在拴留过程中起重要作用，是介导运输囊泡和靶位膜之间首次接触的决定性因子。COG（conserved oligomeric golgi）复合体是进化上保守的多亚基拴留复合体（multisubunit tethering complex，MTC），是细胞内膜泡运输和维持高尔基体稳定性及完整性所必需的因子。在酵母和哺乳类细胞中，COG是八聚体复合体，定位于高尔基体，负责由COPI介导的高尔基体驻留蛋白比如糖基化酶lycosyltransferase在高尔基体内部的逆向膜泡运输。到目前为止，许多先天性糖基化障碍（congenital disorders of glycosylation，CDG）患者已被鉴定为COG复合体中的突变所致，说明了COG复合体在糖基化过程中的重要性。本综述将结合前人对COG复合体的研究成果对其最新研究进展进行概括性叙述。

英文摘要：

In eukaryotic cells, vesicle trafficking is the most basic approach of life activities and is the basis for the transport and exchange of macromolecular material. Membrane trafficking initiates from the budding of the transport vesicles on the donor membrane, then moves along the cytoskeleton, tether and anchor on the target membrane to complete fusion. The tether factors play an important role in the process of tethering, which is a decisive factor of the first contact between the transport vesicles and the target membrane. COG complex （conserved oligomeric golgi） is an evolutionarily conserved multisubunit tethering complex （MTC）, which is anessential factor for vesicle traffickingaswell asstability and integritymaintaining of the Golgi apparatus. In yeast and mammalian cells, COG is an octamer complex localized on the Golgi apparatus, which is involved in COPI-mediatedGolgi-res- ident proteins, such asglycosyl enzyme and lycosyl transferases, in intra-Golgi retrograde vesicle transporting. So far, many CDG （congenital disorders of glycosylation） patients have been identified with deficiencies in the COG complex, which showed the importance of COG complex in the course of glycosylation. In this review, we made a general statement of the latest research progress of COG complex based on our predecessors.