中文摘要：

欧洲起源的人口上的背景基因协会研究为发展 dyslexia.Here 作为一个危险性地点识别了 DCDC2 基因，我们寻求了在我们拿了的汉中国 origin.Methods 的孩子与发展阅读困难调查 DCDC2 多型性的协会 76 个诵读困难者孩子和 79 非诵读困难者上的基因协会学习匹配的盒子控制 controls.We 从口头的 mucosal 房间样品和 genotyped 孤立 DNA 二 DCDC2 代码顺序单身者 nucleo

英文摘要：

Background Genetic association studies on populations of European origin have identified the DCDC2 gene as a susceptibility locus for developmental dyslexia.Here,we sought to investigate the association of DCDC2 polymorphisms with developmental dyslexia in children of Han Chinese origin.Methods We undertook a case-control genetic association study on 76 dyslexic children and 79 non-dyslexic matched controls.We isolated DNA from oral mucosal cell samples and genotyped two DCDC2 coding-sequence single nucleotide polymorphisms,rs2274305 and rs6456593,in each sample using SNaPshot single nucleotide extension.We compared the allele and genotype frequencies between the groups using the X2 test and analyzed the relationship between dyslexia and the polymorphism at both loci using unconditional logistic regression.We also predicted haplotypes and compared their frequencies between the two groups.Results The differences in the genotype distribution and the allelic genes of the two single nucleotide luci of the DCDC2 gene,rs2274305 and rs6456593,between the two dyslexic and non-dyslexic groups were statistically meaningless （P 〉0.05）.The differences in the haplotype distributions of the DCDC2 gene between the dyslexic and normal group were statistically meaningless （P 〉0.05）.Conclusion The DCDC2 gene may not be a susceptibility factor for developmental dyslexia among the Han Chinese.However,methodological issues may have prevented the detection of oositive associations.