中文摘要：

目的探讨脊髓损伤后应用姜黄素对组织形态及大鼠行为学的作用。方法雌性Wistar大鼠72只按随机数字表法分为6组：①单纯损伤组;②姜黄素预处理组（术前30 min,300 mg/kg,腹腔注射）;③~⑤姜黄素大、中、小剂量治疗组（大300 mg/kg、中100 mg/kg、小剂量30 mg/kg,腹腔注射）和⑥甲强龙治疗组（30 mg/kg,静脉滴注）。以50 g力的动脉瘤夹钳夹T9~T10胸段脊髓1 min造模,按计划给药。术后2、8周处死大鼠,HE染色观察脊髓组织形态变化;伤后1 d,1~8周每周行BBB评分及斜板评分实验。结果 HE染色示伤后8周,姜黄素治疗组[（30.07±8.75）、（68.40±12.90）、（87.67±11.49）]与单纯损伤组（150.28±27.31）、甲强龙治疗组（109.78±16.5）相比明显缩小了组织空洞面积,姜黄素预处理组（125.57±18.35）也较单纯损伤组空洞范围小（P〈0.05）。行为学功能与形态学结果相一致,后肢运动评分显示脊髓损伤后完全性后肢瘫痪的各组大鼠逐渐恢复运动功能,姜黄素大、中、小剂量组2、8周[2周：（32.50±2.74）、（30.83±2.04）、（28.33±4.08）;8周：（61.67±5.16）、（57.50±2.74）、（55.00±3.16）]的行为功能均显著优于单纯损伤组[2周：（27.50±2.73）;8周：（38.33±2.58）]和甲强龙治疗组[2周：（30.00±3.16）;8周：（49.17±3.76）],大剂量组效果最好（P〈0.05）,姜黄素预处理组在术后4周起[4周：（33.33±2.58）;6周：（37.50±2.74）;8周：（44.17±2.04）]也较单纯损伤组表现出更好的行为学功能。结论姜黄素可能通过缩小脊髓损伤后空洞面积,促进大鼠后肢功能恢复。

英文摘要：

Objective To study the effect of curcumin on tissue morphology and behavior after spinal cord injury（SCI） in rats.Methods With random number tables,seventy-two female Wistar rats were divided into six groups： a SCI group,a curcumin pretreatment group（30 min before SCI,300 mg/kg,i.p.）,three curcumin treatment groups including high-dose（300 mg/kg,i.p.）,medium-dose（100 mg/kg,i.p.）,and low-dose（30 mg/kg,i.p.） groups,and a methylprednisolone（MP） treatment group（30 mg/kg,i.v.）.Rats in each group underwent SCI operation through clamping T9-10 thoracic spinal cords with 50-gram-force aneurysm clips for 1 min,and received drugs according to a preset schedule.Rats were sacrificed in two and eight weeks after SCI operation to observe the changes of spinal cord tissue morphology with HE staining.The Basso,Beattie and Bresnahan（BBB） locomotor rating scale and inclined plane test were used to evaluate rat behavioral consequences after SCI at the time points of 1 day and every week（up till 8 weeks） after SCI.Results HE staining results demonstrated that after 8 weeks,the tissue cavity areas of curcumin treatment groups（high-dose 30.07±8.75,medium-dose 68.40±12.90,and low-dose 87.67±11.49） were significantly smaller than those of SCI group（150.28±27.31） and MP treatment group（109.78±16.5）.Curcumin pretreatment group also exhibited a smaller tissue cavity area（125.57±18.35） than SCI group（P0.05）.The behavioral function results were consistent with the morphological results.BBB scores of rats in all groups showed gradual motor function recovery from complete hind limb paralysis caused by SCI.The inclined plane test scores showed that the behavioral function of rats in curcumin treatment groups（2 weeks after SCI,high-dose 32.50±2.74,medium-dose 30.83±2.04,and low-dose 28.33±4.08;8 weeks after SCI,high-dose 61.67±5.16,medium-dose 57.50±2.74,and low-dose 55.00±3.16） were significantly better than that in SCI group（2 weeks after SCI,27.50±2.73;8 weeks after S