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Casein kinase Ⅱ interacts with prion protein in vitro and forms complex with native prion protein in vivo
  • ISSN号：1672-9145
  • 期刊名称：《生物化学与生物物理学报：英文版》
  • 时间：0
  • 分类：R341.9[医药卫生—基础医学]
  • 作者机构：[1]中国疾病预防控制中心病毒病预防控制所传染病预防控制国家重点实验室,北京市102206
  • 相关基金：国家重点基础研究发展规划项目（973计划）（No.2007CB310505）,国家传染病重大专项（No.2009ZX10004-101）,国家自然科学基金（No.30800975,31100117）,传染病预防控制国家重点实验室自主研究面上课题（No.2011SKLID211）
作者： Jianming Chen Chen Gao Qi Shi Guirong Wang Yanjun Lei Bing Shan Baoyun Zhang Chenfang Dong SongShi Xin Wang Chan Tian Jun Han Xiaoping Dong[1]
关键词： 朊病毒, 构象转化, 朊病毒现象, 酵母, prion disease , conformational conversion , prion-like phenomenon , yeast
中文摘要：

朊病毒病是一种由朊病毒侵染动物神经系统并引发神经退行性症状的传染性疾病。朊病毒是由正常朊蛋白PrP^C通过构象转化形成具蛋白酶抗性的异常朊蛋白PrP^Se的病原微生物。最新研究表明，朊蛋白通过构象转变形成新的功能分子的现象在生物界中普遍存在，并与正常生物功能密切相关。通过研究类朊蛋白现象可以有助于揭示朊病毒感染机制以及深化对生物遗传多样性的了解。

英文摘要：

Priori disease is an infectious disease that is induced by prion infection of mammal nervous system and accompanied with neurodegenerative symptom. Prion is an etiological factor for prion disease and derived from conformational conversion between normal type PrPc and abnormal type PrPso. According to recent reports, prion-like phenomenon is a wide hereditary phenomenon in biological kingdom and associated with the normal functions of relative factors. Study of prion-like phenomenon will help to reveal mechanism of prion disease.

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Immune Responses in Wild-type Mice Against Prion Proteins Induced Using a DNA Prime-Protein Boost Strategy
Doppel-induced cytotoxicity in human neuronal SH-SY5Y cells is antagonized by the prion protein
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朊病毒病相关细胞凋亡
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Establishment of Hamster- and Human-PRNP Transgenic Mice
Clinical and Familial Characteristics of Ten Chinese Patients with Fatal Family Insomnia
Immune Responses in Wild-type Mice Against Prion Proteins Induced Using a DNA Prime-Protein Boost Strategy
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Molecular interaction between prion protein and GFAP both in native and recombinant forms in vitro.
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Different expression levels of CK2 subunits in the brains of TSEs.
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PrP及其缺失突变体与GFAP体外相互作用的初步研究
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Establishment of a Stable PrP^Sc Panel from Brain Tissues of Experimental Hamsters with Scrapie Strain 263K
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Generation of Genetic Engineering Monoclonal Antibodies against Prion Protein.
The full-length human tau protein formed complex with PrP and some GSS- and fCJD-related PrP mutants
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α-Synuclein与14-3-3蛋白在体外分子间相互作用的鉴定
Recombinant Neural Protein PrP Can Bind with Both Recombinant and Native Apolipoprotein E In Vitro
Doppel-induced cytotoxicity in human neuronal SH-SY5Y cells is antagonized by the prion protein
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Tau融合蛋白及其缺失突变体与朊蛋白的体外作用分析
期刊信息
  • 《生物化学与生物物理学报：英文版》
  • 北大核心期刊（2004版）
  • 主管单位:
  • 主办单位:中国科学院上海生物化学研究所
  • 主编：
  • 地址：上海岳阳路319号
  • 邮编：200031
  • 邮箱：abbs@sibs.ac.cn
  • 电话：021-54920956 54920955
  • 国际标准刊号：ISSN：1672-9145
  • 国内统一刊号：ISSN：31-1940/Q
  • 邮发代号:4-210
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,英国农业与生物科学研究中心文摘,荷兰文摘与引文数据库,美国生物医学检索系统,美国剑桥科学文摘,美国科学引文索引（扩展库）,美国生物科学数据库,英国动物学记录,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,英国英国皇家化学学会文摘,中国北大核心期刊（2000版）
  • 被引量:5851