乙交酯(GA)和己内酯在辛酸亚锡催化下经聚合反应合成了乙交酯-己内酯无规共聚物(Px)。体外加速降解研究结果表明,Px的降解过程大致分为三个阶段:0 h~12 h,12 h~36 h和36 h~72 h。Px中GA含量越高,其变化越接近于聚乙醇酸。
Poly( glycolic acid-co-caprolactone)( Px) were synthesized by polymerization of glycolic acid with caprolactone using stannous octoate as the catalyst. In vitro accelerated degradation of Px were investigated. The results showed that the degradation process of Pxcan be divided into the following three stages: 0 h ~ 12 h,12 h ~ 36 h and 36 h ~ 72 h. Pxwith high GA content exhibited faster degradation rate.