中文摘要：

目的探讨汉族、维吾尔族肺结核患者在抗结核药物治疗后血清中一氧化氮（NO）、总一氧化氮合酶（TNOS）、诱导性一氧化氮合酶（iNOS）以及内皮型一氧化氮合酶（e NOS）的含量以及民族间的差异。方法选取肺结核患者汉族129例,维吾尔族122例,用硝酸还原酶法测定血清NO含量,化学法测定一氧化氮合酶含量。结果汉族、维吾尔族患者血清NO分别为（124.62±18.24）,（89.98±13.28）μmol·L^-1;汉族患者血清TNOS、iNOS、e NOS的浓度分别为（29.79±2.77）,（22.42±3.36）,（7.37±3.56）U·m L^-1;维吾尔族患者分别为（25.25±3.57）,（18.90±2.47）,（6.34±2.66）U·m L^-1。维吾尔族患者血清NO、TNOS、iNOS浓度显著低于汉族患者（P〈0.05）;两民族男性NO浓度均高于女性（P〈0.05）。两民族NO含量偏胖组显著高于偏瘦组与正常组（P〈0.01）。治疗类型与痰检类型的分析显示,两民族NO及一氧化氮合酶含量差异均无统计学意义（P〉0.05）。结论 NO参与肺结核患者免疫作用,其含量在两民族患者体内有差异。该研究可为不同民族肺结核患者体内NO表达差异的相关机制提供参考资料。

英文摘要：

Objective To investigate the levels of serum nitric oxide（ NO）,total of nitric oxide synthase（ TNOS）,inducible nitric oxide synthase（ iNOS） and endothelial nitric oxide synthase（ eNOS） of the Han and Uygur patients with pulmonary tuberculosis treated with anti tuberculosis drugs,and analyze the relationship among the level of NO and NOS.Methods A total of 129 patients of Han and 122 patients of Uygur were collected,the levels of serum NO and NOS were measured by the principle of nitrate reductase and spectrophotography,respectively.Results The serum concentrations of NO,TNOS,iNOS and e NOS in the Han patients were（ 124.62 ± 18.24） μmol ·L^-1,（ 29.79 ± 2.77）,（ 22.42 ± 3.36）,（ 7.37 ±3.56） U·m L^-1,respectively,significantly higher than those of Uygur patients,which were（ 89.98 ± 13.28） μmol·L^-1,（ 25.25 ±3.57）,（ 18.90 ±2.47）,（ 6.34 ±2.66） U·m L^-1（ P〈0.05）.The concentration of NO in male was higher than that in female（ P〈0.05）.The concentration of NO in BMI≥24 kg·m-2group was apparent higher that in the BMI≤18.5kg·m^-2and BMI in 18.5 - 23.9 kg·m^-2group（ P〈0.05）.Meanwhile,the analysis of types of treatment and sputum examination indicated thatthere was no significant difference in the content of NO and NOS between the two ethnic groups（ P〈0.05）.Conclusion NO was involved in the immune function of patients with pulmonary tuberculosis,the study on the difference of the concentrations of NO in Han and Uygur patients will provide a reference for the relevant mechanisms of NO expression in different national tuberculosis patients.