中文摘要：

本研究旨在探讨日粮铜水平对雏鸭肾脏抗氧化功能的影响。360只1日龄天府肉鸭随机分为6组,分别喂以对照日粮（Cu 8 mg.kg^-1）和高铜日粮（Cu 100 mg.kg^-1,高铜Ⅰ组;Cu 200 mg.kg^-1,高铜Ⅱ组;Cu 400mg.kg^-1,高铜Ⅲ组;Cu 600 mg.kg^-1,高铜Ⅳ组;Cu 800 mg.kg^-1,高铜Ⅴ组）6周。高铜Ⅱ组、Ⅲ组、Ⅳ组和Ⅴ组肾脏组织丙二醛含量、游离脂肪酸含量及羟自由基含量显著升高（P〈0.01）,高铜Ⅴ组肾脏CuZn-SOD活性显著降低（P〈0.01或P〈0.05）。同时,高铜Ⅲ、Ⅳ和Ⅴ组血清铜蓝蛋白（CP）活性和高铜Ⅴ组血清CuZn-SOD活性显著降低（P〈0.01或P〈0.05）,高铜Ⅲ、Ⅳ组血清CuZn-SOD活性降低,但不显著（P〉0.05）。结果表明,日粮铜含量达到或超过400 mg.kg^-1可引起肾脏和血清抗氧化酶活性降低,抗氧化功能受损,肾脏组织自由基和过氧化产物产生过量,造成细胞损伤,最终导致肾脏功能降低。

英文摘要：

The experiment was conducted with the objective of examining the effect of dietary high copper on the antioxydic function of kidney in ducklings.360 one-day-old Tianfu meat ducklings were randomly divided into six groups and feed on diets as follows： Controls（Cu 8 mg·kg^-1） and high copper（Cu 100 mg·kg^-1,high copper groupⅠ;Cu 200 mg·kg^-1,high copper groupⅡ;Cu 400 mg·kg^-1,high copper group Ⅲ;Cu 600 mg·kg^-1,high copper group Ⅳ;Cu 800 mg·kg^-1,high copper groupⅤ） for six weeks.Compared with those of control group,the renal free fatty acids,malondialdehyde and hydroxy radical contents in high copper groups Ⅱ,Ⅲ,Ⅳ and Ⅴ,and the renal cuprozinc-superoxide dismutase（CuZn-SOD） in group Ⅴ were increased（P〈0.01 or P〈0.05）.Also,the serum copper-protein（CP） activities in high copper groups Ⅲ,Ⅳ and Ⅴ and the serum CuZn-SOD activities in group V were lower（P〈0.01 or P〈0.05） than that in control group.The results showed that dietary copper exceed 200 mg·kg^-1 impaired renal antioxydic function,and the renal function was finally depressed.