中文摘要：

瞄准：为了调查胃的 mucosal 的机制， demage 走水路由释放 peptide-6 (GHRP-6 ) 的生长荷尔蒙导致了沉浸抑制应力(WRS ) 和它的预防。方法：男 Wistar 老鼠受到有意识或无意识(anesthetized ) WRS，简单抑制(SR ) ，免费游泳(FS ) ，非水液体沉浸，没有水接触的沉浸，或老鼠被放在沙包围的一个笼子。探索除皮肤刺激以外影响压力反应的敏感结构，一个组老鼠把他们的眼睛堵塞。颈的双边的箱子 vagotomy 或颠茄碱注射在一些老鼠被执行处于 mucosal 损坏估计副交感的角色。胃的 mucosal 损害，酸产量和心率可变性被测量。血浆高血压蛋白原酶， endothelin-1 和 thromboxane B2 和胃的热震惊蛋白质 70 也是 assayed。GHRP-6 被注射[intraperitoneal (IP ) 或 intracerebroventricular (ICV )] 在应力到的发作前的 2 h 观察它 mucosal 损害的潜在的预防。结果：为 6 h 的 WRS 导致了严肃的胃的 mucosal 损害[损害区域，吗 WRS 81.8 ??????????倠??????????€ ??????????????倠呌???????????????????????????????????????????????????????ㄠ?€ ′??????????????????倠？？

英文摘要：

AIM：To investigate the mechanism of gastric mucosal demage induced by water immersion restraint stress（WRS） and its prevention by growth hormone releasing peptide-6（GHRP-6）.METHODS：Male Wistar rats were subjected to conscious or unconscious（anesthetized） WRS,simple restraint（SR）,free swimming（FS）,non-water fluid immersion,immersion without water contact,or rats were placed in a cage surrounded by sand.To explore the sensitivity structures that influence the stress reaction besides skin stimuli,a group the rats had their eyes occluded.Cervical bilateral trunk vagotomy or atropine injection was performed in some rats to assess the parasympathetic role in mucosal damage.Gastric mucosal lesions,acid output and heart rate variability were measured.Plasma renin,endothelin-1 and thromboxane B2 and gastric heat shock protein 70 were also assayed.GHRP-6 was injected [intraperitoneal（IP） or intracerebroventricular（ICV）] 2 h before the onset of stress to observe its potential prevention of the mucosal lesion.RESULTS：WRS for 6 h induced serious gastric mucosal lesion [lesion area,WRS 81.8 ± 6.4 mm 2 vs normal control 0.0 ± 0.0 mm 2,P 〈 0.01],decreased the heart rate,and increased the heart rate variability and gastric acid secretion,suggesting an increase in vagal nervecarrying stimuli.The mucosal injury was inversely correlated with water temperature（lesion area,WRS at 35 ℃ 56.4 ± 5.2 mm 2 vs WRS at 23 ℃ 81.8 ± 6.4 mm 2,P 〈 0.01） and was consciousness-dependent.The injury could not be prevented by eye occlusion,but could be prevented by avoiding contact of the rat body with the water by dressing it in an impermeable plastic suit.When water was replaced by vegetable oil or liquid paraffin,there were gastric lesions in the same grade of water immersion.When rat were placed in a cage surrounded by sand,there were no gastric lesions.All these data point to a remarkable importance of cutenuous information transmitted to the high neural center that by vagal nerves reaching the gas