中文摘要：

合成铜绿假单胞菌群体感应信号分子类似物作为细菌生物膜抑制剂。以呋喃甲醛为原料合成5-羟基-3，4-二氯-2（5H）．呋喃酮，与不同长度碳链的烷酸5-位成酯，合成了8个5-烷酸酯基-3，4-二氯-2（5H）-呋喃酮，其结构经NMR和MS表征。初步生物活性测试结果表明，化合物2c，2d，2e，2f和2h对铜绿假单胞菌生物膜的形成有明显的抑制作用，尤其是化合物2e，对ATCC27853的生物膜抑制率高达70％以上。

英文摘要：

To study the biofilm inhibitor quorum sensing autoinducer analogs of Pseudomonas aeruginosa, the analogs of its quorum sensing antoinducer AHLs were synthesized. The 5-hydroxyl-3,4-dichloro-5H-furan-2-one was yielded from 2-furaldehyde, and then acylated at C-5 hydroxyl group with different length of alkyl acids. Eight target compounds were synthesized. All the compounds were confirmed by NMR and MS. The preliminary bioassay test indicated that compounds 2c, 2d, 2e, 2f and 2h showed remarkable effects on biofilm inhibition of Pseudomonas aeruginosa, especially compound 2e, inhibition ratio reached as high as 70% on ATCC 27853.