中文摘要：

目的：探讨人脑胶质瘤中β-catenin的表达及与细胞增殖的相关性。方法：用免疫组化法观察了47例胶质瘤标本β-catenin、cyclin D1、增殖细胞核抗原（PCNA）的表达，并分析其相关性。结果：在胶质瘤中β-catenin、cyclin D1、PCNA均随肿瘤恶性程度增高而增高（P分别为0．017、0．017、0．027），相关分析发现β-catenin、cyclin D1、PCNA的表达两两相关（P〈0．001，P〈0．001和P=0．005）：结论：β—catenin表达水平的异常与胶质瘤细胞周期调节紊乱、增殖指数上升有关，因此可能是控制肿瘤细胞增殖活性的候选基因之一。

英文摘要：

Aim： To study the expression of β-catenin and correlate with cell proliferation in human gliomas. Methods： Immunohistochemical study was used to detect β-catenin, cyclin D1 and PCNA expression in 47 glioma samples. Results： The positive cell number of β-catenin, cyclin D1 and PCNA increased was associated with the degree of malignancy of tumors. The differences of positive rate and expression level between the low-grade and high-grade tumors were statistically significant. In addition, the expression of β- catenin, cyclin D1 and PCNA was correlated well with each other. Conclusion：β-catenin overexpression may lead to the disturbance of cell cycle and proliferation.β-catenin may be one of the candidate to inhibit the cell proliferation in gliomas.