中文摘要：

Apoptosis 在禁止肿瘤生长，前进和抵抗到反肿瘤治疗起一个关键作用。我们假设了那在 apoptotic 基因的基因变体可以影响肺癌症的预后。测试这个假设，我们从 12 基因选择了 38 潜在地功能的单个核苷酸多型性( SNP )( BAX ， BCL2 ，出价， CASP3 ， CASP6 ， CASP7 ， CASP8 ， CASP9 ， CASP10 ，船边交货， FASLG 和 MCL1 )在 apoptosis 包含了与 568 非小的房间肺癌症( NSCLC )在一个中国盒子队在肺癌症估计他们的预示的意义病人们。35 SNP 过去质量控制经历了协会分析，其 11 被显示显著地与 NSCLC 幸存被联系， P <；0.05 ) 。在逐步的回归分析的考克斯后面， 3 SNP 独立地与 NSCLC 的结果被联系(出价 rs8190315：P = 0.003；CASP9 rs4645981：P = 0.007 并且船边交货 rs1800682：P = 0.016 ) 。NSCLC 的有利幸存显著地与出价 rs8190315 AG/GG 的遗传型被联系(调整 HR = 0.65， 95% CI：0.49-0.88 ) ， CASP9 rs4645981 AA (HR = 0.22， 95% CI：0.07-0.69 ) 并且船边交货 rs1800682 GG (调整 HR = 0.67， 95% CI：0.46-0.97 ) 。时间依赖者受体操作曲线(巨鸟) 分析表明在在年 5 点的曲线(AUC ) 下面的区域显著地在把这 3 SNP 的风险分数加到临床的风险分数以后从 0.762 ～ 0.819 被增加。留下 32 SNP 显著地没为这 3 SNP 在调整以后与 NSCLC 预后被联系。这些调查结果显示在 apoptotic 小径的出价 rs8190315， CASP9 rs4645981 和船边交货 rs1800682 多型性可以在中国人口涉及 NSCLC 的预后。

英文摘要：

Apoptosis plays a key role in inhibiting tumor growth, progression and resistance to anti-tumor therapy. We hypothesized that genetic variants in apoptotic genes may affect the prognosis of lung cancer. To test this hypoth- esis, we selected 38 potentially functional single nucleotide polymorphisms （SNPs） from 12 genes （BAX, BCL2, BID, CASP3, CASP6, CASP7, CASPS, CASP9, CASPIO, FAS, FASLG and MCL1） involved in apoptosis to assess their prognostic significance in lung cancer in a Chinese case cohort with 568 non-small cell lung cancer （NSCLC） patients. Thirty-five SNPs passing quality control underwent association analyses, 11 of which were shown to be significantly associated with NSCLC survival （P 〈 0.05）. After Cox stepwise regression analyses, 3 SNPs were independently associated with the outcome of NSCLC （BID rs8190315： P = 0.003; CASP9 rs4645981： P = 0.007 and FAS rs1800682： P = 0.016）. A favorable survival of NSCLC was significantly associated with the genotypes of BID rs8190315 AG/GG （adjusted HR = 0.65, 95% CI： 0.49-0.88）, CASP9 rs4645981 AA （HR = 0.22, 95% CI： 0.07-0.69） and FAS rs1800682 GG （adjusted HR = 0.67, 95% CI： 0.46-0.97）. Time-dependent receptor operation curve （ROC） analysis revealed that the area under curve （AUC） at year 5 was significantly increased from 0.762 to 0.819 after adding the risk score of these 3 SNPs to the clinical risk score. The remaining 32 SNPs were not sig- nificantly associated with NSCLC prognosis after adjustment for these 3 SNPs. These findings indicate that BID rs8190315, CASP9 rs4645981 and FAS rs1800682 polymorphisms in the apoptotic pathway may be involved in the prognosis of NSCLC in the Chinese population.