中文摘要：

在哺乳动物体内，线粒体铁蛋白（mitochondrial ferritin，MtFt）是一个无内含子的基因编码的蛋白，与胞质中的H-ferritin具有较高的同源性，也具有亚铁氧化酶的活性，特异性地在线粒体中表达。近年来的研究发现，过表达MtFt可以使线粒体免受由铁引起的氧化损伤。本文主要介绍MtFt在结构功能上的特点，及其在与铁相关的一些神经退行性疾病中的保护作用．

英文摘要：

In the mammalia, mitochondria ferritin （MtFt） was encoded by intronless genes, it has high homology with cytoplasmic of H-ferritin and has ferrousoxidase activity. The MtFt is specifically targeted to mitochondria. Recent studies found that MtFt overexpression had a role in protecting mitochondria from iron-induced damage. This paper mainly introduces the structure and function of MtFt and the defense of MtFt in some of the iron-related neurodegenerative diseases.