中文摘要：

目的观察炎性反应指标C反应蛋白（CRP）、白细胞介素-6（IL-6）、降钙素原（PCT）对HBV病毒感染不同终末期患者的可能影响。方法收集48例HBV相关原发性肝细胞癌及48例肝硬化失代偿患者临床数据及外周血清,检测HBV拷贝数、PCT、IL-6、CRP、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、凝血酶原时间（PT）等指标用于组间比较及相关性分析。结果原发性肝细胞癌与肝硬化失代偿组间HBV拷贝数、PCT、CRP、淋巴细胞及单核细胞计数无明显差异,而肝硬化失代偿期IL-6较肝细胞癌组水平高,中性粒细胞绝对数较肝细胞癌组减少。结论 IL-6水平升高可能与HBV感染终末结局有关,动态监测IL-6有助于评估HBV感染终末的转归。

英文摘要：

Objective We investigate the possible effect of inflammative indicator C reactive protein（CRP）,interleukin-6（IL-6）and procalcitonin（PCT）on the outcome of HBV infection.Methods The clinical data and peripheral serum of 48 patients with HBV related hepatocellular carcinoma and 48 patients with decompensated cirrhosis were collected,HBV copy numbers,PCT,IL-6,CRP,ALT,AST,prothrombin time（PT）and other indicators were tested for comparison and correlative analysis.Results HBV copy numbers,PCT,CRP,lymphocytes and mononuclear cells showed no significant difference between primary hepatocellular carcinoma and decompensated cirrhosis group;however,IL-6level was significantly higher in decompensated liver cirrhosis than in hepatocellular carcinoma,as opposed to the absolute number of neutrophils.Conclusion IL-6increase may be related to final outcome of HBV infection,dynamic monitoring IL-6is helpful to evaluate the prognosis of HBV infection.