目的探讨蒙古族人群炎症标志物血清C-反应蛋白(CRP)与原发性高血压病的关系。方法选用内蒙古左后旗朝鲁吐乡和奈曼旗固日班花乡的32个自然村作为研究现场,以≥20岁蒙古族居民作为研究对象;采取调查问卷方式收集数据,并检测相关物理指标和采集血标本,用Logistic回归模型分析调整后的CRP水平对原发性高血压的影响。结果高血压患者的血清CRP水平(11.34 mg/L)明显高于血压正常者(8.08 mg/L),差异有统计学意义(P〈0.001);收缩压和舒张压水平分别随CRP水平的升高而升高,且存在线性关系(P〈0.001);与CPR的最低四分位数水平组比较,最高四分位数水平组对高血压病的多因素调整OR值为1.41,95%CI=1.06-1.86。结论CRP水平升高可能是高血压患病的独立危险因素。
Objective To explore the association between plasma concentration of C-reactive protein(CRP) and the risk of essential hypertension among Mongolian population.Methods The residents aged 20 or above in thirty two villages of Kezuohou Banner and Naiman Banner in Inner Mongolia were selected as study subjects.The serum levels of CRP,blood pressure were determined and the information on cardiovascular risk factors were collected with questionnaire among the participants.Logistic regression was used to analyze adjusted effect of CRP on essential hypertension.Results The average level of CRP(11.34 mg/L) in the hypertensives was significantly higher than that of in the normotensive(8.08mg/L,P0.001).There was a significant linear relationship between plasma CRP level and systolic blood pressure(P0.001).Compared to the lowest quartile of CRP,the multivariable-adjusted odds ratio(95%CI) of hypertension for the highest quartile was 1.41(1.06-1.86).Conclusion Increased CRP level may be an independent risk factor of hypertension.