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中文摘要：
调节性B细胞（regulatory B cells,Bregs）是一类对自身免疫性炎症反应有负性调节作用的B细胞亚群。Bregs可通过产生白细胞介素-10（interleukin-10,IL-10）、转化生长因子-β（transforming growth factor,TGF-β）等抑制性细胞因子以及细胞间的接触发挥免疫调节作用。进一步研究Bregs与其他调节性免疫细胞之间的相互作用及其在类风湿关节炎（rheumatoid arthritis,RA）炎症免疫反应中的负性调节功能,有助于深入认识此亚群细胞的功能,阐明RA的发病机制,寻找新的RA治疗策略。
英文摘要：
Recent studies indicate that a group of B cells,named as regulatory B cells（Bregs）,had immune regulatory function.The regulatory function may be directly accomplished by the production of regulatory cytokines IL-10 and TGF-β and/or by the ability of B cells to interact with pathogenic T cells to dampen harmful immune responses.With further research about the relationship between Bregs and other regulatory immune cells,as well as their regulatory role in inflammation immune response of rheumatoid arthritis（RA）,we can well understanding the function of Bregs,then provide new ideas of therapies for the treatment of RA.
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