中文摘要：

目的考察自动滑移型生长棒随脊柱生长自动滑动的性能及其对脊柱侧凸的矫形效果。方法采用后路分段小切口的方式建立幼猪的脊柱侧凸模型。建模8周后，将已成功建立模型的幼猪随机分为对照组及治疗组。治疗组中将幼猪取出内固定，并置入生长棒系统。对照组单纯取出后路内固定材料，不予任何治疗。所有幼猪在建模、矫形手术前、矫形手术后即刻及其后每隔4周时间点分别进行全脊柱后前位X线摄片检查，观察脊柱侧凸矫正情况，并测量各组脊柱生长量和治疗组中生长棒系统的体内滑动距离。结果16头幼猪中1头因感染终止观察，其余15头幼猪建模术后8周进展为明显的脊柱侧凸，随机分为生长棒治疗组（n=10）和对照组（n=5）。治疗组中2头幼猪植入生长棒后发生感染，其余幼猪未见明显感染、断钉断棒等征象。治疗组生长棒植入术前Cobb角为（52．1±14．1）°，植入术后即刻Cobb角减小为（25．4±15．2）°，矫形术后8周治疗最终时Cobb角减少至（20．2±11．4）°；对照组造模完成时侧凸Cobb角为（55．2±15．7）。，取出内固定术后即刻Cobb角为（53．6±15．8）°，随访8周后观察其Cobb角为（51．2±17．6）°。治疗组脊柱生长长度为平均14．2cm，生长棒体内滑动39．8mm；对照组取出内固定术后8周内脊柱生长长度为平均14．9cm。治疗组与对照组脊柱增长量差异无统计学意义（P=0．821）。结论自动滑移型生长棒系统能在矫正脊柱侧凸的同时，随脊柱生长而实现生长棒的延长滑动，并且该生长棒对幼猪脊柱的生长发育无显著影响。

英文摘要：

Objective To evaluate the efficacy of a growth-guidance growing rod in an established porcine scoliosis model via the Cobb angle correction and the continued spinal growth. Methods Immature pigs （age ：6 weeks old, weight：6 -8 kg） were instrumented and tethered using a three separate incisions fashion. After considerable seoliosis was induced, the pigs were randomly assigned to an experiment group （EG） and a sham group （SG）. In EG, the growing rod was implanted and the pigs were euthanized 8 weeks postoperatively; while in SG, the whole instrumentations were only removed and the pigs were followed up over a 8-week period. Dorsoventral （DV） X-ray radiographs were taken prior to and immediately after the growing rod implanting surgery, and at 4-week intervals to assess the Cobb angle correeion and instrumentation positioning. The continued spinal growth and the rod sliding were also assessed from the radiographs. Results Of the 16 pigs, one pig encountered infection during the inducement of the experimental scoliosis and thus was excluded from analysis. Of the remaining 15 pigs, all animals developed progressive, structural scoliosis. The 15 pigs were randomized into EG（ n = 10） and SG（ n = 5 ）. Two pigs in EG encountered infection and were also excluded from analysis. Of the remaining 8 pigs in EG, no neurologic complications, implant failure or infection were observed. In EG, the Cobb angle of the seoliosis before thegrowing rod implanted was （ 52. 1 ± 14. 1 ）° and it decreased to （ 25.4 ± 15.2 ）° postoperatively. After 8 weeks, the Cobb angle was （20. 2 ±11.4 ）°. In SG, the Cobb angle of the scoliosis after 8-week tethering period was （55.2 ± 15.7） ° and it decreased to （53.6 ±15.8）° after removal of the tethering. The curvature remained stable （51.2%） during the subsequent 8 weeks. During the 8 -16th week, the spinal height increased 14. 2 cm and radiographic analysis of the growing rod sliding revealed an average distraction of 39.8 mm in EG; while i