中文摘要：

目的探讨IL-1受体拮抗剂（IL-1Ra）对多柔比星（ADR）肾病大鼠的治疗作用。方法采用前瞻性随机方法,通过查随机数字表将无特定病原体（SPF）级雄性SD大鼠随机分为正常对照组（A组,n=10）,ADR肾病组（B组,n=10）,ADR肾病IL-1Ra治疗组（C组,n=10）,ADR肾病9g/L盐水治疗组（D组,n=10）。检测治疗前及治疗后2周各组大鼠尿蛋白、血清IL-1、TNF-α、清蛋白（Alb）、总胆固醇（TC）、BUN、肌酐（Scr）水平。结果B、D组及C组大鼠治疗前血清IL-1、TNF-α水平均明显高于A组（Pa〈0.01）;血清BUN、Scr与A组比较均无显著性差异（Pa〉0.05）;C组大鼠IL-1Ra治疗2周后,24h尿蛋白、血清IL-1、TNF-α、TC水平均较B、D组及C组治疗前明显降低（Pa〈0.01）,24h尿蛋白、血清IL-1、TNF-α均接近A组水平（Pa〉0.05）,血清Alb仍较A组低,二者比较有显著性差异（P〈0.01）,但高于治疗前水平（P〈0.01）,TC明显低于治疗前水平（P〈0.01）,但较A组高,有显著性差异（P〈0.01）,血清BUN、Scr水平各组间比较,均无显著性差异（Pa〉0.05）。结论IL-1Ra能从多方面阻断IL-1在肾病综合征大鼠的发生发展的作用,对改善预后等方面起重要作用,可使ADR肾病大鼠尿蛋白排出减少、提高血清Alb、降低血清TC和IL-1、TNF-α水平;对血清BUN、Scr水平无无影响。

英文摘要：

ObjectiveTo explore the therapeutic effect of interleukin-1 receptor antagonist（IL-1Ra） on rats with adriamycin（ADR）-induced nephrosis.MethodsThe prospective randomized method was used,specific pathogen free（SPF）-class male SD rats were randomly divided into the control group（group A,n=10）,the ADR nephrosis group（group B,n=10）,the ADR nephrosis IL-1Ra treatment group（group C,n=10）,the ADR nephrosis sodium chloride treatment group（group D,n=10）.Before the treatment,and 2 weeks after treatment,the urine protein,serum IL-1,tumor necrosis factor（TNF-α）,albumin（Alb）,total cholesterol（TC）,serum urea nitrogen（BUN）,serum creatinine（Scr） were detected.ResultsThe serum levels of IL-1 and TNF-α in group B,D and C before the administration of IL-1Ra were significantly higher than those in group A（Pa〈0.01）;there was no significant difference between group B,D,C and group A in serum levels of BUN and Scr（Pa〉0.05）;24-hour urine protein,serum IL-1,TNF-α and TC levels in group C after 2 weeks treated with IL-1Ra were significantly lower than those in group B,D and group C before being treated with IL-1Ra（Pa〈0.01）;there was no significant differe-nce of 24-hour urine protein,serum IL-1 and TNF-α levels between group C and group A（Pa〉0.05）.Compared with group A,the level of the serum Alb was significantly lower（P〈0.01）,but was significantly higher than that before treated with IL-1Ra（P〈0.01）;the level of the serum TC was significantly higher（P〈0.01）,but was significantly lower than that before being treated with IL-1Ra（P〈0.01）.The levels of the serum BUN and Scr had no significantly differences among group A,B,C and group D（Pa〉0.05）.ConclusionsIL-1Ra is capable of blocking the occurrence and development of nephrotic syndrome by a variety of means,and may play a critical role in the prognosis of nephrotic syndrome.IL-1Ra may decrease urine protein excretion,increase serum protein,decrease serum TC,IL-1 and TNF-α levels in ADR n