中文摘要：

ATP-结合盒（ATP-binding cassette,ABC）转运蛋白是目前已知最大、功能最广泛的蛋白质家族。多向耐药性（pleiotropic drug resistance,PDR）蛋白是该家族中仅存于植物和真菌中的一个亚族,结构域与其他亚族相反,即核苷酸结合域（nucleotide-binding domain,NBD）位于跨膜结构域（trans-membrane domain,TMD）的N端。目前已发现PDR型转运蛋白具有转运次生代谢产物和参与胁迫反应等方面的功能。植物PDR基因分为5个亚族：I族基因涉及多种生物和非生物胁迫反应,II￣V族基因功能研究甚少。植物PDR基因在器官水平、化学及环境因素影响下具有特异性较好的表达谱。本文系统阐述了植物PDR型转运蛋白基因的进化、结构及其功能,为理解植物PDR型转运蛋白在生物分子转运和复杂生理功能方面提供一个基础框架。

英文摘要：

ATP-binding cassette （ABC） transporters are present in all beings and constitute a very large protein family. Among the ABC transporters, the pleiotropic drug resistance （PDR） family is relatively particular, since its members are found only in fungi and plants and have a different configuration compared with other subfamilies, that is, the nucleotide binding domain precedes the transmembrane domain. It has been found that the PDR are involved in responses to stress and secondary matabolite transportation. The plant PDR genes reported so far can be subdivided into five clusters based on the amino acid sequence. Most of them belong to subfamily I and are involved in responses to abiotic and biotic stress. In subfamily II to V, only a few members have been characterized. These genes show a spectrum of specific expression patterns, at the organ level and in response to various chemical and environmental factors. In this review, we elucidates the phylogenetic process, protein structure and function of plant PDR gene, outlining a basic framework for understanding the plant PDR gene.