中文摘要：

目的：观察中药复方对荷瘤裸鼠一般状态及血清雌激素水平的影响。方法：将造模成功小鼠随机分为对照组、三苯氧胺（TAM）组、乳结合组（乳岩宁方＋TAM）和益结合组（益气养阴方＋TAM）。每日灌胃一次，连续给药21天，隔日测量裸鼠体重，绘制体重变化曲线；分别于用药前、实验第10天、21天用小鼠自主活动测试仪检测小鼠5分钟内自主活动次数。处死裸鼠前摘眼球取血，ELISA法检测小鼠血清中雌二醇（ E2）和孕酮（Progesitn，简称P）水平。结果：体重：TAM组裸鼠体重下降最明显，为（3.18±0.048）g，乳结合组次之，为（2.5±0.034）g，益结合组（1.3±0.019）g，各组间比较有统计学意义（ p﹤0.01）。自主活动次数：实验第10、21天检测裸鼠活动次数，各实验组明显低于其余各组（p﹤0.01）。雌激素水平：含TAM组血清中雌二醇（E2）和孕酮（P）的水平明显低于对照组（p﹤0.01），乳结合组的E2水平明显低于TAM组（p﹤0.01），益结合组的E2水平与TAM组对比无统计学意义（ p﹥0.05），而两个中药结合组的孕酮水平明显低于对照组（ p〈0．01）。结论：中药复方能改善荷瘤裸鼠一般状态，减轻TAM带来的裸鼠体重下降，改善活动能力，与TAM合用可明显降低体内雌激素水平。

英文摘要：

Objective：To observe the effect of Chinese Herbal Compound formula on the general state and estrogen of tumor-bearing nude mice. Methods：Mice were randomly divided into control group,tamoxifen（ TAM）group,Ru combined group（ Ruyanning Recipe＋TAM）and（ Yiqi Yangyin Recipe ＋TAM）. Then decoction was given to mice for 21 days,body weight was recorded every other day and drew the curved line of weight change,the ability of activity was detected before experiment,on the tenth and twenty-first day. The serum Estradiol（E2）and Progesterone（P） level of mice was tested by ELISA method. Results：Body weight：The decline of body weight in TAM group was the most significant,Ru combined group was second ,Yi combined group was third ,the difference was significant（ p﹤0. 01）. Automatic activity：TAM group was lower than other groups（p﹤0. 01）. Estrogen level：the serum E2 and P level in TAM group was lower than the control group（p﹤0. 01）,the serum E2 of Ru combined group was lower than TAM group（p﹤0. 01）,but there was no significant difference between Yi combined group and TAM group. The two combined groups could decrease the serum P level when compared with that of the control（p﹤0. 01）. Conclusion：Chinese Herbal Compound formula can enhance the general state of mice,decrease the decline of body weight,in-crease the ability of activity,can decrease the level of estrogen obviously on tumor-bearing nude mice.