中文摘要：

目的：探讨利用磁共振弥散加权成像（DWI）评价改良线栓法制作的大鼠大脑中动脉阻塞（MCAO）模型的价值。方法：33只Wistar大鼠随机分为假手术组3只、永久缺血0．5h组15只、永久缺血1．5h组15只。各组于术后相应时间点分行DWI扫描。结果：以神经学症状判定脑梗死造模成功的27例中，DWI检查只有17例出现高信号，TTC染色证实为梗死区。结论：判定脑梗死造模是否成功的条件中，应用神经功能评分联合磁共振检查，会使有关的实验结果更为科学可信。

英文摘要：

Objective： To assess the value of rat middle cerebral artery occlusion （MCAO） model produced by modified zea-longa method with MR DWI. Methods： Thirty-three Wistar rats were divided into three groups： pseudo-operative group（n=3）, permanent ischemia for 0.5 h group （n=15） and permanent ischemia for 1.5 h group（n=15）. DWI were performed. Results： 27 MCAO models were judged successfully by neurological symptoms, only 17 of them demonstrated high signal intensity on DWI. Conclusion： Neurologic functional score combined with MRI for assessing MCAO model could make the relative experimental results more scientific and confident.