中文摘要：

普鲁士蓝是一种美国食品和药物管理局批准的、作为临床上治疗铊等放射性元素中毒的解毒剂,具有良好的生物相容性及生物安全性。普鲁士蓝纳米粒子在尺寸和结构上的可调控性及本身的性能,使得其在药物输运、分子影像、基因治疗、光热治疗肿瘤等肿瘤的诊断和治疗方面发挥着重要作用。本文以肿瘤诊疗方面的医学应用需求为背景,综述了基于普鲁士蓝的纳米诊疗剂在光声成像（PA）、核磁共振成像（MRI）、超声成像（US）、多模式成像,及作为光热转换剂和药物传输系统（DDS）,实现对肿瘤的光热治疗、化疗和基因治疗等研究现状和发展趋势。

英文摘要：

With good biocompatibility and biological safety, the Prussian blue（PB） is used as a clinical medicine for the treatment of radioactive exposure, which is approved by the USA Food and Drug Administration. Owing to the easiness of the control of size, structure,surface modification and its other good performances, the PB nanoparticles（PB NPs） play an important role in the biomedical field including the drug delivery system（DDS）, the molecular imaging, the gene therapy, and the photothermal therapy. This paper reviews the most recent research advances and discusses the future development trends of the applications of the PB-based nanotheranostics in the diagnosis including the photoacoustic imaging（PA）, the magnetic resonance imaging（MRI）, the ultrasonic imaging（US） and the multimodal imaging, as well as in the therapy including the photothermal therapy, the gene therapy and the chemotherapy.