中文摘要：

奶牛酮病是围产期奶牛常见的营养代谢性疾病,给奶牛业造成了巨大的损失。奶牛酮病发生时,相关的能量代谢激素也发生了明显的变化,主要是胰高血糖素和胰岛素。腺苷酸活化蛋白激酶被认为是机体的能量感受器,一些能量代谢激素可以引起其活性的变化。本文就胰高血糖素和胰岛素对腺苷酸活化蛋白激酶信号转导通路发生作用机制做一论述,旨在为下一步研究奶牛酮病提供理论支持。

英文摘要：

Cow ketosis is a common nutritional and metabolic disease during perinatal,which has caused tremendous losses to the dairy industry.Related energy metabolic hormones have undergone tremendous changes when ketosis occurs,mainly including glucagon and insulin.Adenosine mo no phosphate-activated protein kinase（AMPK） is considered to be an energy sensor,some energy metabolic hormones can cause changes of AMPK activity.This article focused on the role of glucagon and insulin in AMPK signal transduction pathways aimed at providing theoretical support for further research in cow ketosis.