中文摘要：

分别以甘油磷脂酰胆碱和1,4-丁二醇为引发剂开环丙交酯,制备了含磷脂酰胆碱的聚乳酸（PLA-PC）和聚乳酸（PLA）,比较了两者在诱导矿化中的差异.用傅立叶红外光谱仪（FTIR）、X-射线衍射仪（XRD）和扫描电子显微镜（SEM）对PLA-PC膜表面形成的矿化物进行了表征.结果表明,形成的矿化物为羟基磷灰石（HAP）,PLA-PC膜有利于成核和生长,晶体呈片状,并随矿化时间延长,HAP晶粒逐渐增大,晶片厚度也逐渐变大.

英文摘要：

Polylactide containing phosphorylcholine （PLA-PC） and polylactide （PLA） were synthesized with lactide （LA） as monomer, glycerophosphorylcholine and 1,4-butanediol as ring-opening initiators respectively. The comparison investigation of inducing mineralization on PLA-PC and PLA films was conducted. The result demonstrated that mineralized products could form on the film of PLA-PC as well as on the film of PLA in the simulated body fluid （SBF） of pH 6. 8. Moreover,formation of the mineralized products was easier on the film of PLA-PC than on the film of PLA. The reason for that is phosphorylcholines can migrate to the surfaces of polymers when PLA-PC contacts with water, and PLA-PC can combine with more Ca^2＋ than PLA because phosphoryl in PLA-PC can combine with Ca^2＋ owing to the interaction between negative charge and positive charge. Fourier-transform infrared （FTIR）, X-ray diffraction （XRD） and scanning electron microscopy （SEM） were used to characterize the mineralized products formed on the surface of PLA-PC films. The results showed that the mineral crystal was hydroxylapatite （HAP） and the crystal had a laminated structure. PLA-PC films are good for nucleation and development of crystals. The crystalline grains and crystalline thickness grew with increasing mineralization time. Therefore, PLA-PC is a promising biodegradable scaffolds material for bone tissue engineering.