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U-shaped association between telomere length and esophageal squamous cell carcinoma risk： a case-control study in Chinese population

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分类：Q255[生物学—细胞生物学] S858[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医]
作者机构：[1]Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China, [2]Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, China, [3]Department of Cardiothoracic Surgery, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214043, China, [4]Department of Medical Oncology, the Affiliated Huai 'an First People 's Hospital of Nanjing Medical University, Huai'an 223300, China
相关基金：Acknowledgements This work was supported by grants from the Key Program of National Natural Science Foundation of China （No. 81230067）; National Basic Research Program （973 Program, No. 2013CB910304）; National Natural Science Foundation of China （Nos. 81422042, 81373090, and 81202267）; Science Foundation for Distinguished Young Scholars in Jiangsu （No. BK20130042）; Jiangsu Natural Science Foundation （Nos. BK2012443, BK2012841, and BK2012443）; Doctoral Fund of Ministry of Education of China （No. 20123234120003）; Jiangsu Province Clinical Science and Technology Projects （Clinical Research Center, No. BL2012008）; and Priority Academic Program for the Development of Jiangsu Higher Education Institutions （Public Health and Preventive Medicine）.

作者： Jiangbo Du[1,2], Wenjie Xue[1], Yong Ji[3], Xun Zhu[1], Yayun Gu[1,2], Meng Zhu[1,2], Cheng Wang[1,2], Yong Gao[4], Juncheng Dai[1,2], Hongxia Ma[1], Yue Jiang[1], Jiaping Chen[1,2], Zhibin Hu[1,2], Guangfu Jin[1,2], Hongbing Shen[1,2]

关键词：鳞状细胞癌, 端粒长度, 中国人群, 食管癌, 病例, 单核苷酸多态性, 危险性, SNPS, esophageal squamous cell carcinoma, telomere length, genetic variants, susceptibility, genome-wide association study

中文摘要：

在由维持 chromosomal 正直并且阻止染色体的生物变老的一个关键角色结束的 Telomeres 玩熔化。流行病学的研究建议了 telomere 长度的内部个人的差别能影响倾向到多重癌症，但是关于食道的有鳞的房间癌(ESCC ) 的证据仍然是不明确的。几 telomere 在白种人的长度相关的单个核苷酸多型性(TLSNP ) 在染色体宽的协会研究被报导了。然而，在 ESCC 开发的 telomere 长度和 TL-SNPs 的效果是不清楚的。因此，我们进行了盒子控制研究(1045 个 ESCC 案例和 1433 控制) 在中国人口评估在 telomere 长度， TL-SNPs，和 ESCC 风险之间的协会。作为结果， ESCC 案例显示出全面更短的相对 telomere 长度(RTL )( 中部：1.34 ) 比控制(中部：1.50， P < 0.001 ) 。更有趣地，一个明显的非线性的U字形的协会在 RTL 和 ESCC 风险之间被观察( P < 0.001 )与比率(95%信心间隔)等于到 2.40 的机会( 1.843.14 )， 1.36 ( 1.031.79 )， 1.01 ( 0.761.35 )，并且 1.37 ( 1.031.82 )为个人在第一(最短)，第二，第三，并且第5 (最长) quintile 分别地，在是的第4 quintile 与那些相比引用组。没有重要协会在八报导 TL-SNPs 和 ESCC 危险性之间被观察。这些调查结果建议短或极其长的 telomeres 可以是为在中国人口的 ESCC 的风险因素。

英文摘要：

Telomeres play a critical role in biological ageing by maintaining chromosomal integrity and preventing chromosome ends fusion. Epidemiological studies have suggested that inter-individual differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cell carcinoma （ESCC） was still uncertain. Several telomere length-related single nucleotide polymorphisms （TL- SNPs） in Caucasians have been reported in genome-wide association studies. However, the effects of telomere length and TL-SNPs on ESCC development are unclear. Therefore, we conducted a case-control study （1045 ESCC cases and 1433 controls） to evaluate the associations between telomere length, TL-SNPs, and ESCC risk in Chinese population. As a result, ESCC cases showed overall shorter relative telomere length （RTL）（median： 1.34） than controls （median： 1.50, P 〈 0.001）. More interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk （P 〈 0.001）, with odds ratios （95% confidence interval） equal to 2.40 （1.84- 3.14）, 1.36 （1.03-1.79）, 1.01 （0.76-1.35）, and 1.37 （1.03-1.82） for individuals in the 1st （the shortest）, 2nd, 3rd, and 5th （the longest） quintile, respectively, compared with those in the 4th quintile as reference group. No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility. These findings suggest that either short or extremely long telomeres may be risk factors for ESCC in the Chinese population.

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