中文摘要：

腺苷酸活化的蛋白激酶（AMP activated protein kinase,AMPK）,是细胞内重要的能量感受器,在调控细胞和机体的能量代谢中起到极其重要的作用。活化的AMPK可以增强分解代谢,抑制合成代谢,应对细胞内外环境的刺激。并且影响细胞的生长、增殖、凋亡、自噬等基本生物学过程。肿瘤细胞具有独特的能量代谢方式——Warburg现象,用于应对营养和能量的相对缺乏。AMPK干扰肿瘤细胞的独特能量代谢方式,广泛影响肿瘤的发生、生长、转移,发挥重要的肿瘤拮抗作用。非小细胞肺癌（non-small cell cancer,NSCLC）是常见恶性肿瘤的一种,具有一般恶性肿瘤的特征,近年来在NSCLC的研究进程表明：AMPK及其相关信号分子LKB1,PI3K/AKT,Ca MKKβ,PTEN等与NSCLC密切相关,活化相应通路或抑制相应通路,可显著拮抗NSCLC。从而AMPK及其相关信号分子有可能作为抗NSCLC药物的作用靶点。

英文摘要：

AMP activated protein kinase（AMPK） is an important cellular energy sensor, which takes an exceedingly essential part in the regulation of energy metabolism of the cell and the whole body. Once activated, AMPK can enhance catabolism and inhibit anabolism to adapt to inside or outside environment changes. It can also affect the progress of cell growth, proliferation, apoptosis and autophagy. Tumor cell obtains its peculiar energy metabolism, Warburg effect, for the coordination to the relative shortage of nutrition and energy. The activation of AMPK disturbs tumor cell＇peculiar energy metabolism, and exhibits close relation to the tumor pathogenesis, development and metastasis. Non-small lung cancer（NSCLC） is a commom type of malignant tumor, containing the characteristics of the general malignant tumor. In recent years, the studies of AMPK in NSCLC have indicated that AMPK and its related signal molecules such as LKB1, PI3K/AKT, Ca MKKβ, PTEN and etc. have a tight connection to NSCLC. Activation of some signal pathway and suppression of other pathway both show a significant antagonism toward NSCLC. Thus AMPK and its related signals have a hopeful prospect of function as a possible target for drug development in the treatment of NSCLC.