以2-取代苯氧基烟酰肼为原料,与异硫氰酸酯反应合成了14个结构新颖的2-烷氨基-5-(2-芳氧吡啶-3-基)-1,3,4-噻二唑类化合物,其结构通过1HNMR、IR和元素分析表征。初步生物活性测试结果表明,化合物4j在50mg/L下对黄瓜枯萎病菌Cladosporium cucumerium的抑制率可达70%。
Fourteen novel title compounds were synthesized from 2-substituted phenoxy isonicotinyl hydrazide with isothiocyanate.The structures of the compounds were confirmed by 1H NMR,IR and elemental analysis.The preliminary fungicidal bioassay results showed that the inhibition rate of 4j against Cladosporium cucumerium was 70% at the concentration of 50 mg/L.