中文摘要：

（1iR，1iiR，2iR，2iiR）-Ni，Nii-（1，3-亚苯基双（亚甲基））环己烷-1，2-二胺（HL）作为配体，设计并合成了7种双核铂配合物，并利用IR，1HNMR，13C NMR，ESI—MS和元素分析等进行了表征。通过MTT法测定目标双核铂配合物对人类HepG-2，A549，HCT-116和MCF-7四种癌细胞系的细胞毒性。结果表明，所有的化合物对HepG-2，A549和HCT-116细胞系均表现了良好的细胞毒活性，但对MCF-7细胞系均无活性。其中，以3-羟基环丁烷．1，1-二羧酸为离去基团的配合物P7对HepG-2和A549细胞系的活性优于卡铂．对HCT-116细胞系的活性接近于奥沙利铂。

英文摘要：

Seven diculear platinum complexes with the new chiral ligand, （1iR,1iiR,2iR,2iiR）-Ni,Nii-（1,3- phenylenebis（methylene））dieyclohexane-1,2-diamine （HL）, were designed, synthesized and speetrally characterized by IR, 1H NMR, 13C NMR, ESI-MS and microanalyses. The cytotoxicities of targeted dinuclear platinum compounds against human HepG-2, A549, HCT-116 and MCF-7 cell lines were evaluated by MTT assay. Results indicated that all compounds exhibited positive activity to HepG-2, A549 and HCT-116 cell lines, but none of them showed activity to MCF-7 cell line. Among them, compound PT, owing to 3-hydroxycyclobutane-1,1- diearboxylate as the leaving group, gave better antitumor activity than carboplatin against HepG-2 and A549 cell lines, and close eytotoxicity to oxaliplatin against HCT-116 cell line.