中文摘要：

利用高效液相色谱方法，建立了复方银黄口服液及其原料药材黄芩和金银花的指纹图谱，测定了银黄口服液中黄芩苷和绿原酸的含量。以Lichrospher C18色谱柱（250mm×4．6mmi．d．，5μm）为分离柱，以甲醇和0．1％磷酸水溶液为流动相进行二元梯度洗脱，流速0．6mL／min，在254nm波长下检测。采用夹角余弦和相关系数的方法，计算6批银黄口服液指纹图谱的相似度均在0．99以上，表明银黄口服液的质量未见显著差异。将银黄口服液指纹图谱中的共有峰与原料药材黄芩和金银花的指纹图谱中的共有峰相比较，对其归属进行确认，大部分共有峰可以匹配。

英文摘要：

The chromatographic fingerprint of Chinese traditional medicine, Yinhuang Oral Liq- uid together with its original materials Radix Scutellariae and Flos lonicera was established by high performance liquid chromatography （HPLC）. At the same time, baicalin and chlorogenic acid in the Yinhuang Oral Liquid were also quantitatively determined. The analysis was performed on a Lichrospher C18 column （250 mm × 4.6 mm i. d. , 5 μm） and with gradient elution. The optimum conditions were explored. The mobile phase A was methanol and the mobile phase B was 0. 1% H3PO4 aqueous solution. The wavelength of 254 nm was selected for detection. Finally, the data of fingerprints of 6 samples of Yinhuang Oral Liquid were processed with two different mathematic methods. This proposed method demonstrated good stability for the 6 samples of Yinhuang Oral Liquid. In the comparison of the common peaks in chromatogram of Yinhuang Oral Liquid with those of crude herbs, most of them could be matched well.