中文摘要：

采用Y型微通道,通过反溶剂沉淀法研究了聚乳酸-羟基乙酸共聚物（PLGA）透明纳米分散体的制备过程。实验考察了在丙酮-水体系条件下,PLGA丙酮溶液浓度、总流量、反溶剂流量、溶剂流量和温度等对PLGA纳米分散体颗粒粒径和分布的影响。研究结果表明：固定溶剂与反溶剂流量比为1∶20,随着总流量从21 mL/min增大到63 mL/min时,颗粒粒径从178 nm减小到91 nm,而继续增大总流量到84 mL/min,粒径增大到106 nm;随着反溶剂流量从2 mL/min增大到16 mL/min,颗粒粒径从115 nm增大到141 nm;此外,随着反溶剂流量和PLGA溶液浓度的增大,颗粒粒径呈先减小后增大的趋势;而随着体系温度的下降,粒径显著减小。

英文摘要：

A poly（lactic-co-glycolic acid）（PLGA） nanodispersion has been prepared by using an antisolvent precipitation method in a Y-junction microchannel.The influences of the key parameters—including the concentration of the PLGA solution in acetone,the overall flow rate,the antisolvent flow rate,and the flow rate of the PLGA solution in acetone—on the particle size and size distribution have been explored.The particle size increased from 115 to 141 nm with an increase in the flow rate of the PLGA solution in acetone from 2 to 16 mL/min.However,with increasing overall flow rate at a fixed flow ratio of 20,the particle size decreased from 178 nm（at 21 mL/min） to 91 nm（at 63 mL/min）,and then increased to 106 nm（at 84 mL/min）.The particle size initially decreased,and then increased,with increasing antisolvent flow rate and increasing concentration of the PLGA solution in acetone.