中文摘要：

目的探讨脓毒症休克患者血小板变化与评分的相关性。方法选择2013年3月~2015年10月在我院治疗的脓毒症休克患者48例的临床资料进行回顾性分析。检测患者确诊时PLT,分别在确诊时、确诊后3、5、7天采用APACHEⅡ评分评价患者病情。比较PLT异常组及正常组患者死亡率、不同时间点APACHEⅡ评分,分析确诊时患者PLT水平与APACHEⅡ评分的相关性。结果 PLT异常患者27例,21例正常。PLT正常患者死亡2例,异常患者12例死亡。两组死亡率比较,差异有统计学意义（P〈0.05）。在确诊时、确诊后3、5、7天,PLT异常组患者APACHEⅡ评分均显著高于PLT正常组患者（P〈0.05或P〈0.01）。PLT水平与APACHEⅡ评分呈显著负相关（r=-0.776）。结论脓毒症休克患者血小板水平与APACHE评分呈负相关,血小板下降患者死亡率更高,可以作为评价患者病情及预后评估的指标。

英文摘要：

Objective To discuss correlation between PLT change with APACHEⅡ in sepsis shock. Methods Clinical data of 48 cases with sepsis from Mar 2013 to Oct 2015 were respectively analyzed. PLT of patients was detected at diagnosis, and patient＇s condition was evaluated with APACHEⅡ at diagnosis, and 3, 5, 7 day after diagnosis. Mortality rates of group of normal PLT and group of abnormal PLT, and APACHEⅡ scores in different time were compared, and correlation between PLT changes with APACHEⅡ in sepsis were analyzed. Results 27 cases were with abnormal PLT,and 21 cases with normal PLT. Two cases in group of normal PLT was dead, and 12 cases in group of abnormal PLT were dead, which showed significant difference（P〈0.05）. APACHEⅡ scores of group of abnormal PLT at different time were higher than group of normal PLT（P〈0.05 or P〈0.01）. PLT showed negative correlation with APACHEⅡ score（r =-0.776）. Conclusion PLT shows negative correlation with APACHE Ⅱ score. Cases with low PLT are with high dead rate, which can be used as a index for evaluation of disease and prognosis.